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G Protein-Coupled Inwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.

G-protein-gated inwardly rectifying K + (GIRK) channels play a key role in maintaining resting membrane potential, cell excitability and inhibitory neurotransmission.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GgirkIRK ion channels.

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